In one clinical trial, buspirone was administered to healthy male volunteers at a dosage of 375 mg/day, and produced side effects including nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress. Overdose īuspirone appears to be relatively benign in cases of single-drug overdose, although no definitive data on this subject appear to be available. It is unclear if there is a risk of tardive dyskinesia or other movement disorders with buspirone. Dyskinesia, akathisia, myoclonus, parkinsonism, and dystonia were reported associated with buspirone. In addition, buspirone does not produce euphoria and is not a drug of abuse. Buspirone is relatively well tolerated, and is not associated with sedation, cognitive and psychomotor impairment, muscle relaxation, physical dependence, or anticonvulsant effects. Known side effects associated with buspirone include dizziness, headaches, nausea, tinnitus, and paresthesia. Main article: List of side effects of buspirone Severely compromised liver and/or kidney function.Contraindications īuspirone has these contraindications: SSRI and SNRI antidepressants such as paroxetine and venlafaxine may cause jaw pain/jaw spasm reversible syndrome (although it is not common), and buspirone appears to be successful in treating bruxism on SSRI/SNRI-induced jaw clenching. Miscellaneous īuspirone is not effective as a treatment for benzodiazepine withdrawal, barbiturate withdrawal, or alcohol withdrawal/ delirium tremens. There is some evidence that buspirone on its own may be useful in the treatment of hypoactive sexual desire disorder (HSDD) in women. Buspirone is not known to be effective in the treatment of other anxiety disorders besides GAD, although there is some limited evidence that it may be useful in the treatment of social phobia as an adjunct to selective serotonin reuptake inhibitors (SSRIs). The drug has been shown to be similarly effective in the treatment of generalized anxiety disorder (GAD) to benzodiazepines including diazepam, alprazolam, lorazepam, and clorazepate.
Buspirone take as needed full#
īuspirone has no immediate anxiolytic effects, and hence has a delayed onset of action its full clinical effectiveness may require 2–4 weeks to manifest itself. It is generally preferred over benzodiazepines because it does not activate the receptors that make drugs like alprazolam addictive. Buspirone is used for the short-term and long-term treatment of anxiety disorders or symptoms of anxiety.
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